The Belgian federal and regional research and innovation administrations have prepared a reflection paper outlining key principles and perspectives for the upcoming 10th European Framework Programme for Research and Innovation. Belgium emphasises continuity with the current Horizon Europe programme while advocating for improvements and enhancements. Key guiding principles include maintaining a focus on excellence and impact, advocating for a stable and dedicated budget for R&I, and fostering synergies between European funding programmes to create a unified funding ecosystem. Belgium recommends retaining the three-pillar structure of Horizon Europe for stability and clarity, and emphasises the importance of interdisciplinary and intersectoral collaboration.